A new potential way to treat brain tumours is on the horizon...

A new potential way to treat brain tumours is on the horizon...

Posted 26 November, 2021 at 08:33

Author Jessica McClory on behalf of In Sues Name


Results of early clinical trials suggest that Chimeric Antigen Receptor -T (CAR-T) cells can be adapted successfully to target brain tumours. 

A phase 1 analysis of one next-generation CAR T-cell therapy, reported at the AACR Virtual Special Conference on Brain Cancer, showed it may target and kill tumour cells while eliciting an immune system response. Making the transition from blood cancers to solid tumours, which has been challenging, is a focus of current research and this includes developing and optimizing CAR T cells to treat malignant brain tumours such as glioblastoma. Evidently, in the US at least, there are more CAR-T clinical trials currently open for the treatment of brain tumours than any other solid tumour.

Cellular immunotherapies that specifically target malignant tumours are thought to be a promising approach in cancer medicine. They identify target molecules that are found exclusively on the tumour cells and are recognized by the immune system. Gliomas lack suitable target structures and this is a considerable challenge for developing immunotherapies. However, using an experimental mouse model, researchers have now demonstrated for the first time that transgenic T cells targeting tumour neoepitopes can be used to treat gliomas.

These results were published in the journal Clinical Cancer Research.

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In Sue’s Name was founded in 2014 by David Taylor in memory of his beloved daughter Sue Blasotta, who died in 2011 of brain tumours. Sue was devoted to her husband Joe and their children Sasha and Daniel. She adored her career, first in recruitment with Reed Employment and then caring for ch...

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