It has been reported previously that children with asthma seem to be less likely to develop brain tumours than others. A reduction in the incidence of optic gliomas was also seen in children with Neurofibromatosis type 1 (NF1) brain cancer predisposition who also had asthma. Researchers have proposed a new model in which brain cancer risk is modified by alterations in the function of circulating T cells. In this new mouse study, researchers discovered that asthma causes the T cells to behave in a way that induces lung inflammation but prevents the growth of brain tumours.
This paper on the reduction of glioma formation by T cell decorin-mediated inhibition of microglia is published in Nature Communications.